Structure of PDB 8jn8 Chain A

Receptor sequence
>8jn8A (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]
VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYI
PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKG
AYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK
HADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW
MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE
PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY
VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE
AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP
CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN
L
3D structure
PDB8jn8 The crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668
ChainA
Resolution1.902 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 JA6 A G279 C280 F281 G282 E283 V284 D389 N394 D407 Y419 G194 C195 F196 G197 E198 V199 D304 N309 D322 Y334
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005102 signaling receptor binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0020037 heme binding
GO:0030331 nuclear estrogen receptor binding
GO:0042169 SH2 domain binding
GO:0043274 phospholipase binding
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
GO:0050839 cell adhesion molecule binding
GO:0051117 ATPase binding
GO:0051219 phosphoprotein binding
GO:0070700 BMP receptor binding
GO:0071253 connexin binding
GO:0097110 scaffold protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001545 primary ovarian follicle growth
GO:0001819 positive regulation of cytokine production
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002376 immune system process
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007283 spermatogenesis
GO:0007611 learning or memory
GO:0008284 positive regulation of cell population proliferation
GO:0009410 response to xenobiotic stimulus
GO:0009612 response to mechanical stimulus
GO:0010447 response to acidic pH
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010907 positive regulation of glucose metabolic process
GO:0010954 positive regulation of protein processing
GO:0014856 skeletal muscle cell proliferation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022407 regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030900 forebrain development
GO:0031295 T cell costimulation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0032205 negative regulation of telomere maintenance
GO:0032869 cellular response to insulin stimulus
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033625 positive regulation of integrin activation
GO:0034139 regulation of toll-like receptor 3 signaling pathway
GO:0034332 adherens junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0035306 positive regulation of dephosphorylation
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0036035 osteoclast development
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0038166 angiotensin-activated signaling pathway
GO:0042476 odontogenesis
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043149 stress fiber assembly
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045056 transcytosis
GO:0045087 innate immune response
GO:0045124 regulation of bone resorption
GO:0045453 bone resorption
GO:0045747 positive regulation of Notch signaling pathway
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0045821 positive regulation of glycolytic process
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046718 symbiont entry into host cell
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048477 oogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050847 progesterone receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051222 positive regulation of protein transport
GO:0051385 response to mineralocorticoid
GO:0051450 myoblast proliferation
GO:0051602 response to electrical stimulus
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051902 negative regulation of mitochondrial depolarization
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060576 intestinal epithelial cell development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070542 response to fatty acid
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071375 cellular response to peptide hormone stimulus
GO:0071393 cellular response to progesterone stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071498 cellular response to fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071803 positive regulation of podosome assembly
GO:0071897 DNA biosynthetic process
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098609 cell-cell adhesion
GO:1900182 positive regulation of protein localization to nucleus
GO:1902533 positive regulation of intracellular signal transduction
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1904263 positive regulation of TORC1 signaling
GO:1904385 cellular response to angiotensin
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990646 cellular response to prolactin
GO:2000256 positive regulation of male germ cell proliferation
GO:2000386 positive regulation of ovarian follicle development
GO:2000394 positive regulation of lamellipodium morphogenesis
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2000641 regulation of early endosome to late endosome transport
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 regulation of caveolin-mediated endocytosis
Cellular Component
GO:0002102 podosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction
GO:0032587 ruffle membrane
GO:0043025 neuronal cell body
GO:0044294 dendritic growth cone
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0070161 anchoring junction
GO:0097060 synaptic membrane
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:1902737 dendritic filopodium

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8jn8, PDBe:8jn8, PDBj:8jn8
PDBsum8jn8
PubMed
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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