Structure of PDB 8jl4 Chain A

Receptor sequence

>8jl4A (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]

AELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKP
SAAAASVSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHNGV
SEIACDLAVNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLPPRLRSVDT
FRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPWFVFIMGSSIFL
SMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWDKVRI
PGVLQRLGVTYFVVAVLELLFAKPVPECLSLRDITSSWPQWLLILVLEGL
WLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDDHL
YQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKD
ILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFF
ILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDN
QSHKEHLTQNIVATALWVLIAYILYRKKIFWKI

3D structure

PDB

8jl4 membrane proteins

Chain

Resolution

2.68 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.78: heparan-alpha-glucosaminide N-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	UV6	A	N286 Y287 H297 R372 E499 K563 H614 E615 E618	N163 Y164 H174 R249 E369 K433 H484 E485 E488
BS02	COA	A	R267 L268 V271 D272 R275 M282 F310 F313 M317 S320 S324 K341 R345 V376 L380 S607 Y611 K662	R144 L145 V148 D149 R152 M159 F187 F190 M194 S197 S201 K218 R222 V253 L257 S477 Y481 K532
BS03	CLR	A	L437 P439	L307 P309

Gene Ontology

	Molecular Function
GO:0015019	heparan-alpha-glucosaminide N-acetyltransferase activity
GO:0016746	acyltransferase activity

	Biological Process
GO:0007041	lysosomal transport
GO:0030200	heparan sulfate proteoglycan catabolic process
GO:0051259	protein complex oligomerization

	Cellular Component
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0035579	specific granule membrane
GO:0043202	lysosomal lumen
GO:0070821	tertiary granule membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8jl4, PDBe:8jl4, PDBj:8jl4
PDBsum	8jl4
PubMed
UniProt	Q68CP4\|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase (Gene Name=HGSNAT)

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