Structure of PDB 8jil Chain A

Receptor sequence
>8jilA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
FLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSW
KSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAM
NRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLT
VHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSA
RIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLH
TSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFS
3D structure
PDB8jil Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
ChainA
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NIO A L83 R111 F180 Y284 L74 R102 F171 Y275
BS02 CLR A I116 T119 V120 L195 I107 T110 V111 L186
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0070553 nicotinic acid receptor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0006915 apoptotic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0050995 negative regulation of lipid catabolic process
GO:0070165 positive regulation of adiponectin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jil, PDBe:8jil, PDBj:8jil
PDBsum8jil
PubMed37597514
UniProtQ8TDS4|HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (Gene Name=HCAR2)

[Back to BioLiP]