Structure of PDB 8jhz Chain A

Receptor sequence

>8jhzA (length=2615) Species: 1505 (Paraclostridium sordellii)

SLISKDELIKLAYSIKPREDEYKTILTNLDEYNKLVTINNKDKYLQLKKL
NDSIDIFINKYKKSSRNRALFNLKKDISKEVILIKNSNISPVEKNLHFVW
IGGEVSDTALEYINQWADINRDYNIRVWYDGEAFLVNTLKKAIVEHSTTD
TLQLFEEDIKNPQFDNMKFYKKRMEFIYERQNRFINYYKSEINKPIKPTI
DDIIKSHLVSEYNKNSESLELYRRTSFEKISNNNGVDIRNNNLFTEQELL
NIYNQELLDRENLAAASDLVRLLALKDFGGVYLDVDMLPGIQPDLFKTIS
RPSSIGVDSWEMIKLEAIMKYKKYIKNYTSKNFDKLDQQLKDDFQITLES
KSEKSEIFSKLGNLDVSDLEIKIAFALGSVINQALISKKGSYLTNLVIEQ
VKNRYKFLNQHLNPAIELGGNFSDTTKNFHDSLFNSATSENSMFLTKIAS
YLQVGFMPEARATISLSGPGAYSSAYYDFINLQDNTIEKTLNASDLMEFK
FPESNLSQFTEQEINSLWSFDQASAKYQFEKYVRDYTQESLSEDSELDFN
KNTVLDKNYLLNNKIPSNNVEETGSKNYVHYIIQLQGDDISYESACNLFS
KNPKNSVIIQRNMNESAKSYFLSDNGESISELNKYRIPQRLKNKEKIKVT
FIGHGKDEFNTSEFAKLSVDSLSNEISSFLDIMKLDISPKNVEINLLGCN
MFSYNVNVEETYPGKLLLNNIDKIISTLPNVNKDNITIGANQYEVRINNE
GRKELLDHSGQWLNKEEAIMNDLSSKEYIFFDSIENRPKAKSKNLIELAS
ISDNIKTLLLDTNIDPETKFILNNLKLNIESSIDNNIYYEKLEPVKNIIH
NSIDNLTNEFNLIENVSDELYELKKINNLDDNYLISFEDISKNDSTYTIR
FINKNSGESVHIQTEKEIFLKYGEHITQEINTIKNNIIIDVNGNLIGNIE
LEHAPQVNTLNAAFFIQSLIDYSNNKDVLNNLRTSVKVQLYAQLFSTGLN
TIYDSIQLVNLISNAINDAINVLPTLTEGVPILATILDGISLGAAIKELS
ETNDPLLKKELEAKVGIIAINMSLSLASMISTVIGVGSELAIFLLPIAGI
SAGIPSLVNNELILHDKATSVVNYFTHLSESKKYGPFKLEDDKILSPIDD
LVISEIDFNTDSIKLGTCDILSMEGGSGYTVTNDIDHFFSSPYINSNIPP
LSIYPVMNIQTTNLDFSKDLMMLPNAPSRLLWWETGAVPGLRSLETDGTR
LLDSIRDFYPGKFYWRFYAWFDFAITTLKPVYENTNIKIKLDKNTRNFIM
PTITTDVIRNNLSYSFTGSGGTYSLLLSSHPISTNINLSKDDLWIFNIDN
KVREISIQNGTIKKGNLVRNALSNLDINKNKLTIDNQIINFSGDVDNKYR
YIFLNCSLDDEISLMIEINLFAKSYNLILSGNKDYLISNLSTIINKINNL
GLNSKNISYNYTDEFNNKYFGVISKTNQKSIICYKKGSKNILELYNGNML
LFDSKDFIADDINIFMKDDINTITGKYYIDNNLDISVDFSISLISKNKVK
VNGLYLNEYGYASFLEFIKNSDGHHNTSNFINLFLDNIGFWKLFGFNNIE
FVIDKYFAITGKTDMGYIEFICDNNKNIDIYFGEWKTSSTKNTIFSGNGR
NLIVEPIYDINAGDNISTSIDFSYEYISGIDIYINKILIVPNLYTELVNI
NTDYSSNKYFPEIIVLNTDTFHDKVNINLDSSSLDYEWAIDGSDFILSRY
LEENNRKILQKIRIKDILSNTKSFNKMMIDFKDIKNISLDHIMNNFKSFN
SESELDRDHFGFKTIDSKTYYYNEVGKLVKGSININDSLFYFDTIESNLV
TGWKTINGKTYYFDINNGVAYIGYKTIDGKNFYFDGNGIMQIGVFKVPDG
FKYFAPANTYNNNEEGQTIVYQNKFLTINGKKYYFDNNSKAVTGWQIING
NKYYFDTNTGIAAVGLQIINNNKYYFNPHTAIAATGWQSINNAKYYFDIN
TYIGTTGYKTIDSKNFYFDSNCIMQIGVFKVSDGFKYFAPANTYNNNEEG
QAIVYQNKFLTINGKRYYFDNNSKAVTGWHTIDGKKYYFNPNTAIAATGW
HTIDDKKYYFNPDTAIAATGWHTIDDKKYYFNPNTGITSTGETTINNKSF
YFNDKGIMQIGVFKVPDGFKYFAPANTHNNNLEGQAIVYQNKFLTINGKK
YYFDNNSKAITGWQVIDDKKYYFNSNTAVADTNLCTINNEKYYFSYDGIL
QNGYITIGRLNFYFDSNNDSKMTTGVFKGPNGFEYFAPANTYNNNLEGQA
IVYQNKFLTINGKKYYFDNKSKAVTGWQTIDGKKYYFNPNTAIAAMGWQA
IDGKKYYFNPNTAIATTGWQTIDGKKYYFNPNTAIAATGWQAIDGKKYYF
NPNTATTSIGYTTINSKNFYFNNDGIMQLGVFKGPDGFEYFAPANTHNNN
EEGQSITYQNKFLIFNEDVYYFDSSSKAVTGWRTIDDHRFYFEPNTGIGA
NGYKTLDGKNFYFRNGLPQFGVFKGPDGFEYFAPANTHNNNEEGQSITYQ
NKFLVFLGNRYYFDSSSKAVTGWQTINGNTYYFMPDTAIAAAGGFFTIDG
AIYFFGIDGVKQPGI

3D structure

• PDB: 8jhz Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D545 H655 C700 H759	D544 H654 C699 H758

Gene Ontology

Molecular Function

• GO:0008234 cysteine-type peptidase activity
• GO:0008289 lipid binding
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding
• GO:0090729 toxin activity

Biological Process

• GO:0006508 proteolysis
• GO:0035821 modulation of process of another organism

Cellular Component

• GO:0005576 extracellular region
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0020002 host cell plasma membrane
• GO:0030430 host cell cytoplasm
• GO:0044164 host cell cytosol
• GO:0044174 host cell endosome
• GO:0044175 host cell endosome membrane

External links

• PDB: RCSB:8jhz, PDBe:8jhz, PDBj:8jhz
• PDBsum: 8jhz
• PubMed: 38438396
• UniProt: M9ZTT7