Structure of PDB 8jh4 Chain A

Receptor sequence
>8jh4A (length=1400) Species: 460519 (Komagataella phaffii) [Search protein sequence]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCCGN
TQPVVRKDGMKLWGTWKKSAQPERKLLTPGEILNVFKHISPEDCFRLGFN
EDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANIN
VQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQALQKSGRPVKAI
RARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQVGVPISIAKTLS
YPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHKRAGDIV
LQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVT
SPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQ
DTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGK
QLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMFGVVDKKTVGSG
GGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSIGIGDAIADAST
MKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVSRTLNDA
RDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRI
AFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFFFHAMAGREGLI
DTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDG
TQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIEYAADILGDVEL
QKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRIIQNAQQIFHLD
RAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATSLFQCLVRA
RLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGE
PATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSS
IEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQSPWLLRLELDR
ARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIEEDQML
KRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYKNEELWALETDG
INLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDG
SYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMRCSFEETVEILF
EAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKLLTSLPADYAPT
3D structure
PDB8jh4 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K100 H1390 K99 H1327
BS02 rna A I251 A252 M253 D486 I225 A226 M227 D460
BS03 dna A M253 A310 K318 K333 R345 R351 T832 A833 M227 A284 K292 K307 R319 R325 T806 A807
BS04 ZN A C67 C70 H80 C66 C69 H79
BS05 ZN A C107 C148 C168 C106 C147 C148
BS06 MG A D482 D484 D486 D456 D458 D460
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jh4, PDBe:8jh4, PDBj:8jh4
PDBsum8jh4
PubMed37981206
UniProtC4R4Y0

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