Structure of PDB 8jf3 Chain A

Receptor sequence
>8jf3A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
KDAWEIPRESLRVKLGEVWMGTWNGTTRVAIKTAQVMKKLRHEKLVQLYA
VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV
ERMNYVHRDLRAANILVGENLVCKVADFGLARLPIKWTAPEAALYGRFTI
KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL
HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB8jf3 Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.
ChainA
Resolution2.84648 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C0N A V284 A296 K298 T341 E342 M344 S345 G347 L396 V18 A30 K32 T61 E62 M64 S65 G67 L116
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8jf3, PDBe:8jf3, PDBj:8jf3
PDBsum8jf3
PubMed38248139
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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