Structure of PDB 8jf1 Chain A

Receptor sequence

>8jf1A (length=513) Species: 9606 (Homo sapiens) [Search protein sequence]

DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMV
SQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKC
PPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGAL
LNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLR
NLTFLIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDAR
GDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACA
RLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITK
VGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVG
LSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAVDQILIVLLTTE
MFVGGCLAFILDNTVPGSPEERGLIQWKAGSSLKSYDFPIGMGIVKRITF
LKYIPICPVFKGF

3D structure

PDB

8jf1 Cryo-EM structures of human sodium-dependent vitamin C transporter 1

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AV0	A	H210 I213 V264 L267 C268 Y284 Q287 A288 A292 R293 P426 I427	H181 I184 V221 L224 C225 Y241 Q244 A245 A249 R250 P383 I384
BS02	AV0	A	L32 I221 I222 Q226 R229 K253 I257 I391 K393 T434	L3 I192 I193 Q197 R200 K210 I214 I348 K350 T391
BS03	AV0	A	F200 A203 G204 D205 R206 A207 S209 W211 C433 F436	F171 A174 G175 D176 R177 A178 S180 W182 C390 F393
BS04	Y01	A	A215 I218 I222 I386 I391 C433 T434 G437 A441	A186 I189 I193 I343 I348 C390 T391 G394 A398
BS05	Y01	A	G390 K393	G347 K350
BS06	CLR	A	L179 L329 A330 I333 F502 G505 C506 F509	L150 L286 A287 I290 F452 G455 C456 F459

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008520	L-ascorbate:sodium symporter activity
GO:0015081	sodium ion transmembrane transporter activity
GO:0015143	urate transmembrane transporter activity
GO:0015205	nucleobase transmembrane transporter activity
GO:0015229	L-ascorbic acid transmembrane transporter activity
GO:0015293	symporter activity
GO:0033300	dehydroascorbic acid transmembrane transporter activity

	Biological Process
GO:0006814	sodium ion transport
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0015747	urate transport
GO:0015851	nucleobase transport
GO:0015882	L-ascorbic acid transmembrane transport
GO:0019852	L-ascorbic acid metabolic process
GO:0030324	lung development
GO:0035725	sodium ion transmembrane transport
GO:0070837	dehydroascorbic acid transport

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009925	basal plasma membrane
GO:0016324	apical plasma membrane
GO:0043229	intracellular organelle
GO:0070062	extracellular exosome

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8jf1, PDBe:8jf1, PDBj:8jf1
PDBsum	8jf1
PubMed
UniProt	Q9UHI7\|S23A1_HUMAN Solute carrier family 23 member 1 (Gene Name=SLC23A1)

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