Structure of PDB 8jbl Chain A

Receptor sequence
>8jblA (length=995) Species: 9823 (Sus scrofa) [Search protein sequence]
ERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPN
ALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEPQND
NLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKM
SINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRS
PDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLE
GGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGII
VANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKT
GTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLC
NRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIV
EIPFNSTNKYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHGKEQ
PLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNF
PLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIA
KGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQL
DDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKA
DIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAY
TLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAE
SDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGF
LPIHLLGLRVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVV
VQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVAL
RMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
3D structure
PDB8jbl Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S775 E779 D804 S754 E758 D783
BS02 CLR A F860 E868 T979 C983 P986 F839 E847 T958 C962 P965
BS03 CLR A W924 Y963 P978 W981 F982 F985 W903 Y942 P957 W960 F961 F964
BS04 CLR A E840 S844 E819 S823
BS05 DMU A M942 I948 M921 I927
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0055085 transmembrane transport
GO:0086009 membrane repolarization
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jbl, PDBe:8jbl, PDBj:8jbl
PDBsum8jbl
PubMed37357620
UniProtP05024|AT1A1_PIG Sodium/potassium-transporting ATPase subunit alpha-1 (Gene Name=ATP1A1)

[Back to BioLiP]