Structure of PDB 8jav Chain A

Receptor sequence
>8javA (length=572) Species: 9606 (Homo sapiens) [Search protein sequence]
EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQL
GSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCS
YIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEM
LHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKA
ALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKAC
VVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQ
SVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFH
AERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEA
HDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAI
QIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLF
GEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDA
LEDVSTSPQSTEEVVQSFLISQ
3D structure
PDB8jav Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase.
ChainA
Resolution3.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y338 Y341 Y345 I391 K430 N434 R437 S441 E469 L472 H476 Y515 Y332 Y335 Y339 I385 K424 N428 R431 S435 E463 L466 H470 Y509
BS02 ZN A C54 H89 C48 H83
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jav, PDBe:8jav, PDBj:8jav
PDBsum8jav
PubMed37844242
UniProtQ92624|APBP2_HUMAN Amyloid protein-binding protein 2 (Gene Name=APPBP2)

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