Structure of PDB 8j9g Chain A

Receptor sequence

>8j9gA (length=448) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITDEE
IRRYLFNASTHKRTYDLVTLFNDKIITANKNDEERVDVWFVIVPAQFHDQ
LKARLLEHTIPTQILRESTLAWRDFKNTFGAPIRDFSKIEGHLAWTISTA
AYYKAGGKPWKLGDIRPGVCYLGLVYKKIEKSKNPQNACCAAQMFLDNGD
GTVFKGEVGPWYNPEKGEYHLKPKEAKALLTQALESYKEQNKSYPKEVFI
HARTRFNDEEWNAFNEVTPKNTNLVGVTITKSKPLKLYKTEGAFPIMRGN
AYIVDEKKAFLWTLGFVPKLQSTLSMEVPNPIFIEINKGEAEIQQVLKDI
LALTKLNYNACIYADGEPVTLRFANKIGEILTASTEIKTPPLAFKYYI

3D structure

PDB

8j9g Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	H207 R225 E226 T228 R243 F245 H251 L252 Y321 K395 L423 L433 P438 N439 N468 A469 G475 R481	H148 R166 E167 T169 R184 F186 H192 L193 Y262 K336 L364 L374 P379 N380 N409 A410 G416 R422
BS02	dna	A	R72 K247 I248 K287 E327 Y328 R362 T363 R364 A402 F403 S431 T432 M435	R72 K188 I189 K228 E268 Y269 R303 T304 R305 A343 F344 S372 T373 M376
BS03	MG	A	N468 I507	N409 I448

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8j9g, PDBe:8j9g, PDBj:8j9g
PDBsum	8j9g
PubMed	37932527
UniProt	A0A1I7NFD7

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