Structure of PDB 8j8h Chain A

Receptor sequence

>8j8hA (length=452) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]

RGSMKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQ
KGLQIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEIT
DEEIRRYLFNASTHKRTYDLVTLFNDKIITANKNDEERVDVWFVIVPEEI
FHDQLKARLLEHTIPTQILRESTLAWRDFKNTFGAPIRDFSKIEGHLAWT
ISTAAYYKAGGKPWKLGDIRPGVCYLGLVYKKIEKSKNPQNACCAAQMFL
DNGDGTVFKGEVGPWYNPEKGEYHLKPKEAKALLTQALESYKEQNKSYPK
EVFIHARTRFNDEEWNAFNEVTPKNTNLVGVTITKSKPLKLYKTEGAFPI
MRGNAYIVDEKKAFLWTLGFVPKLQSTLSMEVPNPIFIEINKGEAEIQQV
LKDILALTKLNYNACIYADGEPVTLRFANKIGEILTASTEIKTPPLAFKY
YI

3D structure

PDB

8j8h Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	H207 Q222 I223 L224 R225 T228 R243 F245 H251 T255 P323 E324 L423 S434 E436 N468 D474 G475 R481 I507	H152 Q167 I168 L169 R170 T173 R188 F190 H196 T200 P268 E269 L368 S379 E381 N413 D419 G420 R426 I452
BS02	dna	A	R72 R243 K247 K286 K287 Y328 T363 R364 F403 T432 L433 M435	R75 R188 K192 K231 K232 Y273 T308 R309 F348 T377 L378 M380

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

View graph for
Molecular Function

External links

PDB	RCSB:8j8h, PDBe:8j8h, PDBj:8j8h
PDBsum	8j8h
PubMed	37932527
UniProt	A0A1I7NFD7

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