Structure of PDB 8j8g Chain A

Receptor sequence

>8j8gA (length=1005) Species: 10244 (Monkeypox virus) [Search protein sequence]

GMDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQS
LSPPPFNARPMGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSI
QNATMDEFFNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCF
AKEIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLL
FTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAK
QLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCI
YERNQSSHKGVCGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSI
SKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKADTFAKVLTTGNYVTVDE
DIICKVIRKDILENGFKVVLSCPTLPNDIYKLSFGKDDIDLAQMYKDYNL
NIALDMARYCIHDACLCQYLWEYYGVETKTDAGAATYVLPQSMVFEYRAS
TIIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFD
YNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITV
HCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTE
KAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLE
SVLNGAELSNGMLRFANTLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVY
GDTDSVFTEIDSQDVDKSIEIAKELERLINSRVLFNNFKIEFEAVYKNLI
MQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTR
LSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSN
YKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKT
YETIIDRSFKLGSNQRIFYEVYFKRLTSEIVNLLDNKVLCISFFQRMFGS
RPTFY

3D structure

PDB

8j8g Structural basis of human monkeypox viral DNA replication inhibition by brincidofovir and cidofovir

Chain

Resolution

2.79 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	D751 K826 G827 R832 R833 D834 H897 Y900 K901 R1000	D752 K827 G828 R833 R834 D835 H898 Y901 K902 R1001
BS02	dna	A	F38 K96 F108 N109 H307 Y496 R497 S499 T500 Y528 E529 G530 G531 N665 S666 G669 L670 F673 N675 K803 K804 I947 R974 Y1004	F39 K97 F109 N110 H308 Y497 R498 S500 T501 Y529 E530 G531 G532 N666 S667 G670 L671 F674 N676 K804 K805 I948 R975 Y1005
BS03	TXJ	A	S552 L553 Y554 R634 K661 N665	S553 L554 Y555 R635 K662 N666
BS04	CA	A	D166 E168 D462	D167 E169 D463
BS05	CA	A	D549 Y550 N551 D753	D550 Y551 N552 D754

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006310	DNA recombination
GO:0039693	viral DNA genome replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8j8g, PDBe:8j8g, PDBj:8j8g
PDBsum	8j8g
PubMed	38735603
UniProt	Q5IXW8

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