Structure of PDB 8j7w Chain A

Receptor sequence
>8j7wA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
ISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHM
FFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFF
IFSEGVERALALLLVSILGFVVNLIGIFVFKHGGPSRQILQGVFLHILAD
TLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILM
QRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAP
DADARWILSQTHNIFTQAGVRQLYVQIDFAAM
3D structure
PDB8j7w Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus.
ChainA
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D74 H240 D244 D53 H146 D150
Gene Ontology
Molecular Function
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0042802 identical protein binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0006882 intracellular zinc ion homeostasis
GO:0055085 transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:1904257 zinc ion import into Golgi lumen
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0048471 perinuclear region of cytoplasm
GO:1990674 Golgi cis cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j7w, PDBe:8j7w, PDBj:8j7w
PDBsum8j7w
PubMed37553324
UniProtQ8NEW0|ZNT7_HUMAN Zinc transporter 7 (Gene Name=SLC30A7)

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