Structure of PDB 8j62 Chain A

Receptor sequence
>8j62A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMDPDTFSYNFNNRPILSRRNTVWLCYEVERLDNGTWVKMDQHRGQVYS
ELKYHPEMRFLSLVSKWKLHRDQEYEVTWYISWSPCTKCARDMATFLQEN
THVTLTIFVARLYYFWDPDYQEALRSLAQAGATIKIMNYDEFQHCWSKFV
YSQGAPFQPWDGLDEYSQALSGMLGEILRH
3D structure
PDB8j62 Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H0 T5 Y8 N9 R13 I15 L16 S17 R18 N20 T21 Y47 S48 E49 L50 W81 Y111 Y112 F113 W114 H2 T7 Y10 N11 R15 I17 L18 S19 R20 N22 T23 Y49 S50 E51 L52 W83 Y113 Y114 F115 W116
BS02 rna A K64 K66 K66 K68
BS03 ZN A H53 C84 C87 H55 C86 C89
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8j62, PDBe:8j62, PDBj:8j62
PDBsum8j62
PubMed37419875
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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