Structure of PDB 8j1k Chain A

Receptor sequence
>8j1kA (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
PALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFITW
IEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGT
GYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEP
KFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTG
3D structure
PDB8j1k co-crystal structure of non-carboxylic acid inhibitor with PHD2
ChainA
Resolution2.451 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SY6 A M299 Y303 H313 D315 R322 H374 V376 A385 W389 M91 Y95 H105 D107 R114 H166 V168 A177 W181
BS02 MN A H313 D315 H374 H105 D107 H166
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:8j1k, PDBe:8j1k, PDBj:8j1k
PDBsum8j1k
PubMed
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

[Back to BioLiP]