Structure of PDB 8iys Chain A

Receptor sequence
>8iysA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
CTLSAEDKAAVERSKMIDRNLREDGEKARRELKLLLLGTGESGKSTFIKQ
MRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKA
HAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTK
YYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGG
QRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTI
ITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREF
ILKMFVDLNPDSDKIIYSHFTCATDTENIRAAAAFVFAAVKDTILQLNLK
EYNLV
3D structure
PDB8iys Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A E43 G45 K46 S47 T48 S150 R177 N268 K269 D271 L272 C324 T326 E41 G43 K44 S45 T46 S148 R175 N266 K267 D269 L270 C322 T324
Gene Ontology
Molecular Function
GO:0001664 G protein-coupled receptor binding
GO:0003924 GTPase activity
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:8iys, PDBe:8iys, PDBj:8iys
PDBsum8iys
PubMed37286793
UniProtP50148|GNAQ_HUMAN Guanine nucleotide-binding protein G(q) subunit alpha (Gene Name=GNAQ)

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