Structure of PDB 8ixu Chain A

Receptor sequence
>8ixuA (length=400) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GEFCVIPKMDGQLVEKLGQRLLPWMDRLSSEQLNPSIYVGLRLSSMQAGT
KENLYLHNLKLHYQQCLGCQTKISGGSLALYLLALRANCELLGSRKGDRM
VSQLKWFLEDEKKAIGHHHEGHPHTSYYQYGLSILALCVHRKRVHDSVVG
KLLYAVEHDYFTYQGHLSVDTEAMAGLAFTCLERFNFNSDLRPRITTAIE
TVREKILKAQAPEGYFGNIYSTPLALQMLMTSPGVGLGPACLKARKSLLL
SLQDGAFQNPMMISQLLPVLNHKTYLNLISPDCQAPRVMLVPATEDPVHL
SEVSVTLKVSSVLPPYERTVSVFAGASLEDVLNRARDLGEFTYGTQASLS
GPYLTSVLGKEAGDREYWQLLRVPDTPLLQGIADYKPKNGETIELRLVKM
3D structure
PDB8ixu The structure of the rat vitamin B 12 transporter TC and its complex with glutathionylcobalamin.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 A G103 S104 Y155 D197 N245 Y247 S248 M289 Q292 L376 S377 G378 P379 Y380 L381 Y394 W395 Q396 L397 L405 L406 G408 G76 S77 Y128 D170 N218 Y220 S221 M262 Q265 L349 S350 G351 P352 Y353 L354 Y367 W368 Q369 L370 L378 L379 G381
Gene Ontology
Molecular Function
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8ixu, PDBe:8ixu, PDBj:8ixu
PDBsum8ixu
PubMed38636663
UniProtQ9R0D6|TCO2_RAT Transcobalamin-2 (Gene Name=Tcn2)

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