Structure of PDB 8ixt Chain A

Receptor sequence

>8ixtA (length=401) Species: 10116 (Rattus norvegicus) [Search protein sequence]

DDKGEFCVIPKMDGQLVEKLGQRLLPWMDRLSSEQLNPSIYVGLRLSSMQ
AGTKENLYLHNLKLHYQQCLLGCQTKISGGSLALYLLALRANCELLGGDR
MVSQLKWFLEDEKKAIGHHHEGHPHTSYYQYGLSILALCVHRKRVHDSVV
GKLLYAVEHDYFTYQGHLSVDTEAMAGLAFTCLERFNFNSDLRPRITTAI
ETVREKILKAQAPEGYFGNIYSTPLALQMLMTSPGVGLGPACLKARKSLL
LSLQDGAFQNPMMISQLLPVLNHKTYLNLISPDCQAPRVMLVPATEDPVH
LSEVSVTLKVSSVLPPYERTVSVFAGASLEDVLNRARDLGEFTYGTQASL
SGPYLTSVLGKEAGDREYWQLLRVPDTPLLQGIADYKPKNGETIELRLVK
M

3D structure

PDB

8ixt The structure of the rat vitamin B 12 transporter TC and its complex with glutathionylcobalamin.

Chain

Resolution

1.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	B12	A	G103 S104 Y155 D197 N245 Y247 S248 M289 Q292 L376 S377 G378 P379 Y380 L381 Y394 W395 Q396 L397 L405 L406 G408	G80 S81 Y129 D171 N219 Y221 S222 M263 Q266 L350 S351 G352 P353 Y354 L355 Y368 W369 Q370 L371 L379 L380 G382
BS02	GSH	A	S153 Y154 Y190 S195 T198	S127 Y128 Y164 S169 T172

Gene Ontology

	Molecular Function
GO:0031419	cobalamin binding
GO:0046872	metal ion binding
GO:0140355	cargo receptor ligand activity

	Biological Process
GO:0006824	cobalt ion transport
GO:0015889	cobalamin transport

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0009897	external side of plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ixt, PDBe:8ixt, PDBj:8ixt
PDBsum	8ixt
PubMed	38636663
UniProt	Q9R0D6\|TCO2_RAT Transcobalamin-2 (Gene Name=Tcn2)

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