Structure of PDB 8ixm Chain A

Receptor sequence

>8ixmA (length=309) Species: 287 (Pseudomonas aeruginosa)

QRIGVIGTGAIGGFYGLMLAHAGHDVHFLLRSEFEAVNRAGLSLNSAVHG
FRRLAPVQAYHSAQDMPPCDWLLVGAKTTGNHELAPLIRAAAAPGAKVLL
LQNGLGVEERLRPLLPESLHLLGGLCFICVHRGEPGVIEHQAYGGVNLGY
HSGPADERRRREIVEEGAALFRESGLESTAMPDLEQARWQKLVWNIPYNG
LSVLLKSSTAPLMANADSRSLIEAIMEEVIGAAGACGFILPEGYADQLLA
ATERMPDYRPSMYHDFAHGRPLELAAIYAAPLARAAAAGYRMPRVEALHQ
ALRFLEAQP

3D structure

• PDB: 8ixm KEtopantoate reductase of Pseudomonas
• Chain: A
• Resolution: 1.96 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.169: 2-dehydropantoate 2-reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G12 G14 A15 I16 R36 S37 G80 A81 K82 G85 E88 L106 Q107 N108 I133 V135 R137 Y263 E278	G7 G9 A10 I11 R31 S32 G75 A76 K77 G80 E83 L101 Q102 N103 I128 V130 R132 Y258 E273
BS02	COI	A	N108 F132 I133 K196 W199 N200 N204 Y263 S266	N103 F127 I128 K191 W194 N195 N199 Y258 S261

Gene Ontology

Molecular Function

• GO:0008677 2-dehydropantoate 2-reductase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0015940 pantothenate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8ixm, PDBe:8ixm, PDBj:8ixm
• PDBsum: 8ixm
• PubMed: 38962820
• UniProt: Q9I2Y5