Structure of PDB 8iws Chain A

Receptor sequence
>8iwsA (length=890) Species: 9606 (Homo sapiens) [Search protein sequence]
TMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDI
SEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVT
VAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSV
GDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSN
IAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLL
GKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVT
VTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHI
FTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAV
IRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKC
VHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKA
RMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVS
IKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVA
VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTG
TDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALT
LISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRN
WKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCF
VFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQ
KVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKI
3D structure
PDB8iws Structure and transport mechanism of the human calcium pump SPCA1.
ChainA
Resolution3.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D350 T352 D644 D335 T337 D629
BS02 CA A V303 A304 I306 E308 N738 D742 V288 A289 I291 E293 N723 D727
BS03 BEF A D350 T352 T570 D335 T337 T555
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0140613 P-type manganese transporter activity
Biological Process
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0008544 epidermis development
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0030036 actin cytoskeleton organization
GO:0032468 Golgi calcium ion homeostasis
GO:0032472 Golgi calcium ion transport
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0070588 calcium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
GO:0098629 trans-Golgi network membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0033106 cis-Golgi network membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iws, PDBe:8iws, PDBj:8iws
PDBsum8iws
PubMed37258749
UniProtP98194|AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (Gene Name=ATP2C1)

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