Structure of PDB 8isq Chain A

Receptor sequence
>8isqA (length=261) Species: 1793721 (Stenotrophomonas sp. KCTC 12332) [Search protein sequence]
VSDADFATLEKTSGGRLGVCLWHPASGARYGHRMDERFPMCSTVKFPLAA
AILHRVDAGKLSLDQRVAVRQGDIISHSPFTERHVGKDMTVRDLCRATLI
ISDNAAANLLLPLIDGPAGLTAFLQAQGDRITVSARNQPELNHFAPGDPR
DTTSPAAMAGNLQRFLLGDVLSPASRQQLADWLIDNQTGDARLRAGLPQG
WRVGDKTGSNGQDTSNDIAALWPLAGGAPWLLSCYLQGSALDDDGRDGIL
RQVGELAGARL
3D structure
PDB8isq Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZZ7 A S70 H105 S130 R220 T235 G236 S237 G240 S42 H77 S102 R192 T207 G208 S209 G211
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:8isq, PDBe:8isq, PDBj:8isq
PDBsum8isq
PubMed38588869
UniProtA0A126NGE0

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