Structure of PDB 8isp Chain A

Receptor sequence
>8ispA (length=259) Species: 1793721 (Stenotrophomonas sp. KCTC 12332) [Search protein sequence]
DADFATLEKTSGGRLGVCLWHPASGARYGHRMDERFPMCSTVKFPLAAAI
LHRVDAGKLSLDQRVAVRQGDIISHSPFTERHVGKDMTVRDLCRATLIIS
DNAAANLLLPLIDGPAGLTAFLQAQGDRITVSARNQPELNHFAPGDPRDT
TSPAAMAGNLQRFLLGDVLSPASRQQLADWLIDNQTGDARLRAGLPQGWR
VGDKTGSNGQDTSNDIAALWPLAGGAPWLLSCYLQGSALDDDGRDGILRQ
VGELAGARL
3D structure
PDB8isp Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q53 A S70 H105 S130 N132 R220 T235 G236 S237 S40 H75 S100 N102 R190 T205 G206 S207
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:8isp, PDBe:8isp, PDBj:8isp
PDBsum8isp
PubMed38588869
UniProtA0A126NGE0

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