Structure of PDB 8is4 Chain A

Receptor sequence

>8is4A (length=452) Species: 82983 (Obesumbacterium proteus)

KRTLLFKNAELLVTMDDERREIRGGCLLVEGNRIVAVGGDELCAAPADEE
IDLRGHIVIPGLINTHHHMFQSLTRVIPDAQDGELFDWLNNLYPIWAGLT
PEMIRISTQTAMAELMLSGCTTSSDHLYVYPNGCRLDDSIDGAREIGMRF
HACRGSMSVGRSKGGLPPDELVENEQAILEDSLRLIHSYHDAQRYSMLRI
ALAPCSPFSVSRELMVKTAQMAREQGVSLHTHLAENDSDVSYSQTHFGMT
PAQYAEDLGWVGSDVWHAHCVKLDRAGISLFARTGTGVAHCPCSNMRLAS
GIAPIRAMLDEGVSVGLGVDGSASNDAGNMIAETRQAMLLQRVGFGPDAM
NARQALEIATRGGAKVLNRDDIGYLATGMAADFVAFDLNTLNLAGAKHDP
LAALVFCTPGNVAFSVINGQVVIREGVLQTIDLPSVVQQHNRLACLLVNR
HR

3D structure

• PDB: 8is4 Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.
• Chain: A
• Resolution: 1.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	URF	A	H70 W90 Y130 E237	H68 W88 Y128 E235
BS02	ZN	A	H68 H70 H234 D322	H66 H68 H232 D320

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 30 13:32:49 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '8is4', asym_id = 'A', title = 'Structural characterization of an isocytosine-sp...application potential in the anti-cancer therapy.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='8is4', asym_id='A', title='Structural characterization of an isocytosine-sp...application potential in the anti-cancer therapy.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0016787,0016810', uniprot = '', pdbid = '8is4', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0016787,0016810', uniprot='', pdbid='8is4', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>