Structure of PDB 8is0 Chain A

Receptor sequence
>8is0A (length=377) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
PRGSHMVMLAQQWRDARPKVAGLHLDSGACSRQSFAVIDATTAHARHEAE
VGGYVAAEAATPALDAGRAAVASLIGFAASDVVYTSGSNHAIDLLLSSWP
GKRTLACLPGEFGPNLSAMAANGFQVRALPVDDDGRVLVDEASHELSAHP
VALVHLTALASHRGIAQPAAELVEACHNAGIPVVIDAAQALGHLDCNVGA
DAVYSSSRKWLAGPRGVGVLAVRPELAERLQPRIPPSDWPIPMSVLEKLE
LGEHNAAARVGFSVAVGEHLAAGPTAVRERLAEVGRLSRQVLAEVDGWRV
VEPVDQPTAITTLESTDGADPASVRSWLIAERGIVTTACELARAPFEMRT
PVLRISPHVDVTVDELEQFAAALREAP
3D structure
PDB8is0 Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE.
ChainA
Resolution3.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G81 S82 N83 F106 S155 D180 A182 Q183 S200 R202 K203 G87 S88 N89 F112 S161 D186 A188 Q189 S206 R208 K209
BS02 DHA A A23 R202 K203 R337 R348 A29 R208 K209 R343 R354
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:1990411 hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:8is0, PDBe:8is0, PDBj:8is0
PDBsum8is0
PubMed38072054
UniProtA0R5M7|EGTE_MYCS2 Probable hercynylcysteine sulfoxide lyase (Gene Name=egtE)

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