Structure of PDB 8iqu Chain A

Receptor sequence
>8iquA (length=545) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
LSIPSMLRQCVNLHPDGTAFTYIDYERDSEGISESLTWSQVYRRTLNVAA
EVRRHAAIGDRAVILAPQGLDYIVAFLGALQAGLIAVPLSAPLDERVDAV
VRDAKPNVVLTTSAIMGDSPPTVAVDQLDLDSPIVDDSLQTTAYLQYTRT
PAGVMITYKNILANFQQMISAYFADTGAVPPLDLFIMSWLPFYHDMGLVL
GVCAPIIVGCGAVLTSPVAFLQRPARWLQLMAREGQAFSAAPNFAFELTA
AKAIDDDLAGLDLGRIKTILCGSERVHPATLKRFVDRFSRFNLREFAIRP
AYGLAEATVYVATSQAGQPPEIRYFEPHELSAGQAKPCATGAGTALVSYP
LPQSPIVRIVDPNTNTECPPGTIGEIWVHGDNVAGGYWEKPDETERTFGG
ALVAPSAGTPVGPWLRTGDSGFVSEDKFFIIGRIKDLLIVYGRNHSPDDI
EATIQEITRGRCAAIAVPSNGVEKLVAIVELNNDTERLSFVTREVTSAIS
TSHGLSVSDLVLVAPGSIPITTSGKVRRAECVKLYRHNEFTRLDA
3D structure
PDB8iqu Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis.
ChainA
Resolution2.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.57: long-chain fatty acid adenylase/transferase FadD23.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 649 A M195 I196 D222 M223 L227 F265 S300 E301 R302 A328 Y329 G330 L331 A332 V336 D446 M168 I169 D195 M196 L200 F238 S273 E274 R275 A301 Y302 G303 L304 A305 V309 D419
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0046506 sulfolipid biosynthetic process
GO:0071766 Actinobacterium-type cell wall biogenesis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iqu, PDBe:8iqu, PDBj:8iqu
PDBsum8iqu
PubMed37522751
UniProtP9WQ47|FAA23_MYCTU Long-chain-fatty-acid--AMP ligase FadD23 (Gene Name=fadD23)

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