Structure of PDB 8io3 Chain A

Receptor sequence
>8io3A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
GTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLI
MLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGI
VVEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVERALRIVRFTKIL
SLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDG
CLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQ
QAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQ
VEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIIN
FTCRGLVAHMDPSFVTAVLTKLRFEVFQPGDLVVREGKMYFIQHGLLSVL
TDGSYFGESVRADTYCRLYSLSVDHFNAVLEE
3D structure
PDB8io3 Cryo-EM structure of human HCN3 channel with cilobradine
ChainA
Resolution3.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VXI A W234 F238 Y242 L244 W168 F172 Y176 L178
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
GO:1903351 cellular response to dopamine
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0043025 neuronal cell body
GO:0044316 cone cell pedicle
GO:0098855 HCN channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8io3, PDBe:8io3, PDBj:8io3
PDBsum8io3
PubMed
UniProtQ9P1Z3|HCN3_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Gene Name=HCN3)

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