Structure of PDB 8inl Chain A

Receptor sequence

>8inlA (length=648) Species: 9606 (Homo sapiens)

MSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQL
WLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRI
KPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATF
RKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAV
PKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEADITAE
FLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQ
ILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVA
LAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPL
GVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNL
FGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRC
LAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMA
QPITPGPPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGA

3D structure

• PDB: 8inl LSD1 in complex with S2172
• Chain: A
• Resolution: 2.62 Å

Enzymatic activity

• Enzyme Commision number: 1.14.99.66: [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DJ0	A	F538 A539 Y761 A809 T810	F361 A362 Y584 A625 T626
BS02	FAD	A	G285 G287 S289 L307 E308 A309 R310 G315 R316 G330 A331 M332 V333 A589 V590 L625 W751 W756 S760 Y761 G800 E801 A809 T810 V811 A814	G115 G117 S119 L137 E138 A139 R140 G145 R146 G160 A161 M162 V163 A412 V413 L448 W574 W579 S583 Y584 G616 E617 A625 T626 V627 A630

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:8inl, PDBe:8inl, PDBj:8inl
• PDBsum: 8inl
• UniProt: O60341|KDM1A_HUMAN Lysine-specific histone demethylase 1A (Gene Name=KDM1A)