Structure of PDB 8ing Chain A

Receptor sequence

>8ingA (length=595) Species: 9925 (Capra hircus)

SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAE
YEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLF
MQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPK
LKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLA
SRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQ
AGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKIL
GAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFG
HMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL
AKKSKLMNQNKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYN
SWRGFCGLSQPKTLKGLQAVLKNKILAKKLLDLYKTPDNIDIWIGGNAEP
MVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFS
RLICDNTHVTKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN

3D structure

• PDB: 8ing Structure of the ternary complex of lactoperoxidase with substrate nitric oxide (NO) and product nitrite ion (NO2) at 1.98 A resolution
• Chain: A
• Resolution: 1.98 Å

Enzymatic activity

• Enzyme Commision number: 1.11.1.7: peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NO	A	Q105 H109	Q105 H109
BS02	HEM	A	M101 G104 Q105 D108 D112 F113 E258 Q259 T344 F347 R348 G350 H351 V354 L433 I436 R440	M101 G104 Q105 D108 D112 F113 E258 Q259 T344 F347 R348 G350 H351 V354 L433 I436 R440
BS03	CA	A	D110 T184 F186 D188 S190	D110 T184 F186 D188 S190
BS04	OSM	A	L224 A225 R271	L224 A225 R271

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:8ing, PDBe:8ing, PDBj:8ing
• PDBsum: 8ing
• UniProt: A0A452E9Y6|PERL_CAPHI Lactoperoxidase (Gene Name=LPO)