Structure of PDB 8ikt Chain A

Receptor sequence
>8iktA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
LTRVDLNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVL
IPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNIT
CITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSL
PCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGC
GAGLLPEPDCRKVTCENGLGCGFAFCRECKEAYHEGECS
3D structure
PDB8ikt Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
ChainA
Resolution2.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C253 H257 C289 C293 C116 H120 C152 C156
BS02 ZN A C365 C368 H373 C377 C226 C229 H234 C238
BS03 ZN A C166 C169 C196 C201 C29 C32 C59 C64
BS04 ZN A C238 C241 C260 C263 C101 C104 C123 C126
BS05 ZN A C332 C337 C352 C360 C195 C200 C215 C221
BS06 ZN A C150 C154 C212 H215 C13 C17 C75 H78
External links
PDB RCSB:8ikt, PDBe:8ikt, PDBj:8ikt
PDBsum8ikt
PubMed39221915
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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