Structure of PDB 8ikm Chain A

Receptor sequence
>8ikmA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
SFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSG
ECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDV
RSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCP
NSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPE
PDCRKVTCGGNGLGCGFAFCRECKEAYHEGECS
3D structure
PDB8ikm Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
ChainA
Resolution1.92 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C150 C154 C212 H215 C6 C10 C68 H71
BS02 ZN A C166 C169 C196 C201 C22 C25 C52 C57
BS03 ZN A C253 H257 C289 C293 C109 H113 C145 C149
BS04 ZN A C365 C368 H373 C377 C220 C223 H228 C232
BS05 ZN A C238 C241 C260 C263 C94 C97 C116 C119
BS06 ZN A C332 C337 C352 C360 C188 C193 C208 C215
External links
PDB RCSB:8ikm, PDBe:8ikm, PDBj:8ikm
PDBsum8ikm
PubMed39221915
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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