Structure of PDB 8ik6 Chain A

Receptor sequence
>8ik6A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
GPSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLI
PNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITC
ITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLP
CVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLVDERAAEQARWTT
KPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
3D structure
PDB8ik6 Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans.
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C150 C154 C212 H215 C12 C16 C74 H77
BS02 ZN A C166 C169 C196 C201 C28 C31 C58 C63
BS03 ZN A C418 C421 C436 C441 C203 C206 C221 C226
BS04 ZN A C253 H257 C289 C293 C115 H119 C151 C155
BS05 ZN A C446 C449 C457 H461 C231 C234 C242 H246
BS06 ZN A C238 C241 C260 C263 C100 C103 C122 C125
External links
PDB RCSB:8ik6, PDBe:8ik6, PDBj:8ik6
PDBsum8ik6
PubMed39221915
UniProtO60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)

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