Structure of PDB 8ijx Chain A

Receptor sequence
>8ijxA (length=983) Species: 9823 (Sus scrofa) [Search protein sequence]
NDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVK
FARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVV
VTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLV
EMKGGDRVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPLETRN
IAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHF
VDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVT
VCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHL
WFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVP
VPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLS
IHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTA
YLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLCFAGLVSM
IDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETV
EDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFA
RTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDA
AKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYL
IYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKR
DRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWE
NHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRR
LSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLV
PMPFSLLIFVYDEIRKLGVRCCPGSWWDQELYY
3D structure
PDB8ijx Deep learning driven de novo drug design based on gastric proton pump structures.
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.19: H(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A X385 T387 D726 X335 T337 D676
BS02 PZ0 A A123 D137 N138 A335 V338 A339 V341 E343 E795 Y799 L811 G812 C813 I816 E820 A73 D87 N88 A285 V288 A289 V291 E293 E745 Y749 L761 G762 C763 I766 E770
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ijx, PDBe:8ijx, PDBj:8ijx
PDBsum8ijx
PubMed37726448
UniProtP19156|ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (Gene Name=ATP4A)

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