Structure of PDB 8iiy Chain A

Receptor sequence

>8iiyA (length=506) Species: 9606,83333 [Search protein sequence]

IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVA
TGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGK
LIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQ
EPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDEALKDAQTNAAAVTIVKPIVYGNVARYFGKKREEDGHTHQWTVY
VKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIII
KIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAM
MQQLLT

3D structure

PDB

8iiy GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.

Chain

Resolution

2.15 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y27 F104 E109 R110 E137 F138 Y139 E141 M142 I143 F144	Y377 F454 E459 R460 E487 F488 Y489 E491 M492 I493 F494
BS02	peptide	A	H71 S73 Y74 G92 W93 G94 E95 F96 F121	H421 S423 Y424 G442 W443 G444 E445 F446 F471
BS03	GLC	A	D-338 K-337 E-241 Y-197 W-122	D13 K14 E109 Y153 W228
BS04	GLC	A	W-290 D-287 E-199 P-198 Y-197 W-12	W60 D63 E151 P152 Y153 W338
BS05	GLC	A	E-308 E-307 R-286 E-199 P-198 W-12 R-8	E43 E44 R64 E151 P152 W338 R342
BS06	GLC	A	K-310 E-308 E-307 R-8	K41 E43 E44 R342

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8iiy, PDBe:8iiy, PDBj:8iiy
PDBsum	8iiy
PubMed	37844223
UniProt	O95619\|YETS4_HUMAN YEATS domain-containing protein 4 (Gene Name=YEATS4); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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