Structure of PDB 8ifo Chain A

Receptor sequence
>8ifoA (length=76) Species: 9606 (Homo sapiens) [Search protein sequence]
KRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITK
RRRKSCQACRFMKCLKVGMLKEGVRL
3D structure
PDB8ifo ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y138 H139 Y140 K149 K153 V198 R199 Y14 H15 Y16 K25 K29 V74 R75
BS02 dna A E146 A147 R154 R177 K178 Q181 R184 E22 A23 R30 R53 K54 Q57 R60
BS03 ZN A C128 C131 C148 C4 C7 C24
BS04 ZN A C164 C180 C183 C40 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8ifo, PDBe:8ifo, PDBj:8ifo
PDBsum8ifo
PubMed36944284
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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