Structure of PDB 8if3 Chain A

Receptor sequence
>8if3A (length=917) Species: 9606 (Homo sapiens) [Search protein sequence]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDLRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSA
LDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNIDLYDVRRRPWY
IQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF
NSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQL
LNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNY
DRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQV
QWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSL
EDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNEPVTLDFLDAELE
NDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDY
SLALVLPTYSFYYIKAKLEDSETLKPDNFEESGYTFIAPRDYCNDLKISD
NNTEFLLNFNEFIDRTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKN
IKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVF
TAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENF
TKDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLV
NISVYAFNKSYDYQSVCESCITEQTQYFFDNDSKSFSGVLDCGNCSRIFH
GEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRK
GPDVCFDNNVLEDYTDC
3D structure
PDB8if3 Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit.
ChainA
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8X9 A V207 Y217 Y236 R241 W243 D452 A453 D491 V169 Y179 Y192 R197 W199 D408 A409 D447
External links
PDB RCSB:8if3, PDBe:8if3, PDBj:8if3
PDBsum8if3
PubMed36933823
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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