Structure of PDB 8ieg Chain A

Receptor sequence
>8iegA (length=64) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTC
NKAFSSNDLLTVHL
3D structure
PDB8ieg Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
ChainA
Resolution3.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C663 H665 C683 C686 C27 H29 C47 C50
BS02 ZN A C648 C651 C671 C12 C15 C35
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:8ieg, PDBe:8ieg, PDBj:8ieg
PDBsum8ieg
PubMed37633270
UniProtQ07457|BRE1_YEAST E3 ubiquitin-protein ligase BRE1 (Gene Name=BRE1)

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