Structure of PDB 8i5x Chain A
Receptor sequence
>8i5xA (length=1273) Species:
9606
(Homo sapiens) [
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GPQSFVHFTKQSLALIEQRIAERKSKEPKPSSDLEAGKQLPFIYGDIPPG
MVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRIS
IKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLV
KILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNNVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL
KHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDS
GQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTL
RAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQPYW
IKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN
LVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLLSVLR
SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
QLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC
MEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDA
NNLQIAVTRIKKGINYVKQTLREFILKAFGKIWWNIRKTCYKIVEHSWFE
SFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKW
IAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL
RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG
KFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLG
YLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGS
FFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK
PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTE
VLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFL
ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALF
NIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQIT
TSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYII
ISFLVVVNMYIAVILENFSVATE
3D structure
PDB
8i5x
Structural mapping of Na v 1.7 antagonists.
Chain
A
Resolution
2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
P5S
A
W1178 W1179 R1182 Y1186 G1249 Y1250
W683 W684 R687 Y691 G754 Y755
BS02
Y01
A
T1255 A1257 L1264
T760 A762 L769
BS03
Y01
A
Y1250 K1251
Y755 K756
BS04
Y01
A
T758 W849 E981
T428 W514 E646
BS05
9Z9
A
L398 E406 F963 L964 L968 S972 I1457 I1759 F1763
L377 E385 F628 L629 L633 S637 I962 I1264 F1268
BS06
T7F
A
T1404 T1448 L1449 F1748
T909 T953 L954 F1253
BS07
LPE
A
P1733 I1737 V1741 S1742
P1238 I1242 V1246 S1247
BS08
LPE
A
Y1658 F1661 F1738 Y1739
Y1163 F1166 F1243 Y1244
BS09
LPE
A
A1257 W1258 V1311 N1312
A762 W763 V816 N817
BS10
LPE
A
F387 Q1478 Y1481 F1645
F366 Q983 Y986 F1150
BS11
LPE
A
Y1481 A1484 M1485 L1488
Y986 A989 M990 L993
BS12
LPE
A
D320 K376 T377 M379 M1655
D299 K355 T356 M358 M1160
BS13
LPE
A
R1218 T1683
R723 T1188
BS14
LPE
A
L1203 A1210 F1211 M1307 F1656 F1684
L708 A715 F716 M812 F1161 F1189
BS15
LPE
A
V253 S257 M1533 A1627
V232 S236 M1038 A1132
BS16
Y01
A
H765 P767 N1391 Y1396
H435 P437 N896 Y901
BS17
LPE
A
H1191 F1194 F1197
H696 F699 F702
Gene Ontology
Molecular Function
GO:0005216
monoatomic ion channel activity
GO:0005248
voltage-gated sodium channel activity
GO:0005261
monoatomic cation channel activity
GO:0005272
sodium channel activity
GO:0005515
protein binding
Biological Process
GO:0006811
monoatomic ion transport
GO:0006814
sodium ion transport
GO:0006954
inflammatory response
GO:0007623
circadian rhythm
GO:0009636
response to toxic substance
GO:0009791
post-embryonic development
GO:0019228
neuronal action potential
GO:0019233
sensory perception of pain
GO:0034220
monoatomic ion transmembrane transport
GO:0035725
sodium ion transmembrane transport
GO:0048266
behavioral response to pain
GO:0050965
detection of temperature stimulus involved in sensory perception of pain
GO:0050974
detection of mechanical stimulus involved in sensory perception
GO:0055085
transmembrane transport
GO:0086002
cardiac muscle cell action potential involved in contraction
GO:0098870
action potential propagation
Cellular Component
GO:0001518
voltage-gated sodium channel complex
GO:0005886
plasma membrane
GO:0016020
membrane
GO:0030424
axon
GO:0033268
node of Ranvier
GO:0034702
monoatomic ion channel complex
GO:0042995
cell projection
GO:0043005
neuron projection
GO:0043679
axon terminus
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8i5x
,
PDBe:8i5x
,
PDBj:8i5x
PDBsum
8i5x
PubMed
37270609
UniProt
Q15858
|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha (Gene Name=SCN9A)
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