Structure of PDB 8i4z Chain A

Receptor sequence
>8i4zA (length=1687) Species: 1079985 (Streptomyces chartreusis NRRL 3882) [Search protein sequence]
QEPIAVLGIGCRFPGGVRSPEDLWDLVDSGGDAVGGLPAGRGWQAGSALD
GVNAGFIHGVEEFDPYFFGLDPVEAAAMDPQQRLLLETTWEAFERAGIDP
VAARGSRTAVYAGVQFGGYPLLMREAPPPQVLDHLGLGNSVGAASGRLAY
QFGLLGGAVTVDTQCTSSIVALHLAVKALRNGECALALAGGACVMSLPTV
LMDFHRRSLLAPDGRSKSFAAAADGVSLAEGAGMLLLERLSDARRNGHPV
MAVIRGTAINQDGATNGIISPSGRAQERVIRAALADGRVTADSVDAVEGH
GVGATLGDGVEVTSLLSTYGQERPAGRPLLLGSVKSNIGHTQTVGAVAGI
VKLVMALRNERLPRTVHVDGPTPHADWSSGTVRLLTEPEPWRRGERVRRA
GLTCLTLSGTNGHLILEEPPADEPAARPANPERTVPLVLSAKSPTALREQ
AERLRATITAAEPVDVGHSLHTTRSSFRHRAVVLGTGREELAAGLDALAG
DRTADGLVRGVARAQGQTALLFGGAGDGTSGDRPADAEGPRTARGLYEAF
PAFAEALDEVTEHLAGLLGPEVRAAVREPGPACAEPTVVGQAVAFALNTA
LHRLLTAFAVRPDATLGHGAGEVAAAYAAGALSLADGAALVTALGRITER
VATGPGASVWVRATEDEVRAALSGSQEQVGAAVAAVDEPGTTVVSGDAGA
VARVAAHWRAHGRATGAPRPARLLLSPDDEQAALAELRAIVAGLAFREPE
VPLLSTVTGQPVEPAELRSAEHWLDHLRGPTRFLDGVRRLRTDGVTRLVG
LDLSGDLTGPAGRSAAGFGEPGRPLLLASVPGGGRPPGQALLSALGELHT
DGVAIDWSQAFEGRGARRVDLPTYPYQKVRCWLVPPEPQVSVVAAPPHPL
LGTALDLVDATGQSFTQQLTPGQVAGVFGQQLYGTPVLPAGARLEWLLAA
ARHGSPDSAWTLTGIRLPGTVSAASGTPVALQTSREDSGDGHRVRAFVKG
PGTGGGRWAERGGATVVPAVTRPAPDRVDPESLPEGLAELDVAEVYRRLW
RQGSDYAEPLRVLRRVWLGGDEAVALVGTADVPTGPSGWSRWAAVLEAAV
QLAALSGSGPRTPVSVDRLEVSGPPSEVVWLRVRHGADGAADAVVLSGEG
VRLAAVQGLRLRPMAGREPAGLAEAPLERHEVVWHALAEDGRPGAIGGGT
GSWLVFSDDPERAAAWCDELALFGVPAVALAGEDAEGRDGTETVPVGTGD
PDVVGKTFAELRERGVTVAGLLVHDAGDAREPASGADDPLDAACRRGGRT
LALVRGFLQEYAEQTPRIVLCSAGAAAGLAGGPPHPAQAPLTALFTSLVW
EHPELPCAQVDLDPAEDPPTVVSLLGQVMRLPGAGRLAVRGGRWFEARLE
RRPAPADRGERLALRPDATYLVAGGDTRHAAAALEWLAARGARSVVLAGA
ESERGDLAGARTTGHAGIERLEHVAVDLSSAADVARLAELCADGRPPLRG
VLLLPQPVAGGGLDELDGARFGAELAGALRGPVELTRRFTDVGLTGGTDF
FVLSTSVVSLPGRAGTVVGSAADAFLTALARHHRQAGLPVVAAAWGPWLE
SVDESDEAPAVAFAEAGVYPAPGGEMLDALLPLPAAGEADGSGEAGLARV
DWDRYLTAGHRPLPYTVLETRASYDEEKAPGFGQNRM
3D structure
PDB8i4z C-N bond formation by a polyketide synthase.
ChainA
Resolution3.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONF A Q147 F148 C197 T438 Q115 F116 C165 T406
Gene Ontology
Molecular Function
GO:0004312 fatty acid synthase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0071770 DIM/DIP cell wall layer assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i4z, PDBe:8i4z, PDBj:8i4z
PDBsum8i4z
PubMed36899013
UniProtA0A2N9BJK0

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