Structure of PDB 8i40 Chain A

Receptor sequence
>8i40A (length=467) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
GLDKVMSLSSAVQDIKNGATLAVGGFGTGGMPHAIMQEIKKMGVRDLIIY
SDGAGVDGYGIGVLFENKQINKMIVSYVGNNKIFARQYLEGDVELEFCPQ
GSLAERMRAGGAGIPAFYTPTAVGTVLQTGGQITKYDKNGGVLKESTPRE
TRFFGGRLYCLENAIKTDFSIVKAWKGDRCGNLVFRGTARNFNVPVGQCG
QTVIAEVENLVENGDIDPDEVHLPGVYVDRVVVPERYQTLIEHRTVTRGE
EVRQRIARRAALEFANGMYVNLGIGIPTESSNYIPAGVNVVLQSENGLIG
MGPFPTEDKVDADWINAGKQTISHLAGSALFDSATSFAMIRGGHMDLTML
GALEVAANGDLANFMIPGKLVKGPGGAMDLVSCGTRVVVTTTHCNKNGDP
KIVERCRLPVTGKHCVCRIITEYAVFDVVDGRLVLKEIAEDTTVDQVKKL
TGVGFDADNVITMPLAP
3D structure
PDB8i40 Crystal structure of ligand complexes of ASCT from Trypanosoma brucei and molecular mechanism in comparison with mammalian SCOT.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.3.5: 3-oxoacid CoA-transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A I298 I300 E319 G375 L377 N387 G400 K425 I274 I276 E295 G351 L353 N363 G376 K401
Gene Ontology
Molecular Function
GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity
GO:0008410 CoA-transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046950 cellular ketone body metabolic process
GO:0046952 ketone body catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Cellular Component
External links
PDB RCSB:8i40, PDBe:8i40, PDBj:8i40
PDBsum8i40
PubMed
UniProtQ386P1

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