Structure of PDB 8i3y Chain A

Receptor sequence
>8i3yA (length=459) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
GLDKVMSLSSAVQDIKNGATLAVGGFGTGGMPHAIMQEIKKMGVRDLIIY
SDGAGVDGYGIGVLFENKQINKMIVSYVGNNKIFARQYLEGDVELEFCPQ
GSLAERMRAGGAGIPAFYTPTAVGTVLQTGGQITKYDKNGGVLKESTPRE
TRFFGGRLYCLENAIKTDFSIVKAWKGDRCGNLVFRGTARNFNVPVGQCG
QTVIAEVENLVENGDIDPDEVHLPGVYVDRVVVPERYQTLIEHRTVTRRI
ARRAALEFANGMYVNLGIGIPTESSNYIPAGVNVVLQSENGLIGMGPFPT
EDKVDADWINAGKQTISHLAGSALFDSATSFAMIRGGHMDLTMLGALEVA
ANGDLANFMIPGKLVKGPGGAMDLVSCGTRVVVTTTHCNKNGDPKIVERC
RLPVTGKHCVCRIITEYAVFDVVDGRLVLKEIAEDTTVDQVKKLTGVGFD
ADNVITMPL
3D structure
PDB8i3y Crystal structure of ASCT from Trypanosoma brucei in complex with Succinyl-CoA.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.3.5: 3-oxoacid CoA-transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SCA A F36 Y87 G297 I298 G299 E319 A341 K343 N387 G399 G400 A401 N419 K420 K425 F26 Y77 G267 I268 G269 E289 A311 K313 N357 G369 G370 A371 N389 K390 K395
BS02 CA A Q211 D239 Q201 D229
Gene Ontology
Molecular Function
GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity
GO:0008410 CoA-transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046950 cellular ketone body metabolic process
GO:0046952 ketone body catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:8i3y, PDBe:8i3y, PDBj:8i3y
PDBsum8i3y
PubMed
UniProtQ386P1

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