Structure of PDB 8i3p Chain A

Receptor sequence
>8i3pA (length=164) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GGMASKWDQKGMDIAYEEAALGYKEGGVPIGGCLINNKDGSVLGRGHNMR
FQKGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAIIMYGI
PRCVVGENVNFKSKGEKYLQTRGHEVVVVDDERCKKIMKQFIDERPQDWF
EDIGERIELQKQQE
3D structure
PDB8i3p crystal structure of yeast cytosine deaminase mutant yCD-RQ-1/8SAH in complex with (R)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.1: cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OS0 A I33 H62 E64 C91 C94 W152 D155 I30 H59 E61 C88 C91 W149 D152
BS02 ZN A H62 C91 C94 H59 C88 C91
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004131 cytosine deaminase activity
GO:0008270 zinc ion binding
GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0046872 metal ion binding
Biological Process
GO:0008655 pyrimidine-containing compound salvage
GO:0019858 cytosine metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044206 UMP salvage
GO:0046087 cytidine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8i3p, PDBe:8i3p, PDBj:8i3p
PDBsum8i3p
PubMed
UniProtQ12178|FCY1_YEAST Cytosine deaminase (Gene Name=FCY1)

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