Structure of PDB 8i3a Chain A

Receptor sequence
>8i3aA (length=562) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
SSSCFPITLKFVDVCYRVKIHEERTILSGVTGMISPGEFMAVLGPSGSGK
STLLNAVAGRLHGSNLTGKILINDGKITKQTLKRTGFVAQDDLLYPHLTV
RETLVFVALLRLPRSLTRDVKLRAAESVISELGLTKCENTVVGNTFIRGI
SGGERKRVSIAHELLINPSLLVLDQPTSGLDATAALRLVQTLAGLAHGKG
KTVVTSIHQPSSRVFQMFDTVLLLSEGKCLFVGKGRDAMAYFESVGFSPA
FPMNPADFLLDLANGVCQTPNVRQTLVTAYDTLLAPQVKTCIEVSHFITT
CIATWFSQLCILLHRLLKERRHESFDLLRIFQVVAASILCGLMWWHSDYR
DVHDRLGLLFFISIFWGVLPSFNAVFTFPQERAIFTRERASGMYTLSSYF
MAHVLGSLSMELVLPASFLTFTYWMVYLRPGIVPFLLTLSVLLLYVLASQ
GLGLALGAAIMDAKKASTIVTVTMLAFVLTGGYYVNKVPSGMVWMKYVST
TFYCYRLLVAIQYGSGEEILRMLFVEEEVIGDVGMWTSVGVLFLMFFGYR
VLAYLALRRIKH
3D structure
PDB8i3a Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25.
ChainA
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V49 I83 S103 G104 G106 K107 S108 T109 Q232 H265 V18 I26 S46 G47 G49 K50 S51 T52 Q175 H208
BS02 MG A S108 D231 Q232 S51 D174 Q175
BS03 ATP A T197 R205 G206 S208 G210 E211 T140 R148 G149 S151 G153 E154
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0015562 efflux transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009737 response to abscisic acid
GO:0009738 abscisic acid-activated signaling pathway
GO:0010496 intercellular transport
GO:0048581 negative regulation of post-embryonic development
GO:0055085 transmembrane transport
GO:0080168 abscisic acid transport
GO:0140352 export from cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i3a, PDBe:8i3a, PDBj:8i3a
PDBsum8i3a
PubMed37666961
UniProtQ84TH5|AB25G_ARATH ABC transporter G family member 25 (Gene Name=ABCG25)

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