Structure of PDB 8i2n Chain A

Receptor sequence
>8i2nA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
LNVIKMKSSDFLESAELDSKVSLAFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST
PLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA
SFKMWSKLNNEEHNELGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWA
IFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEA
NPEARPTFPGIEEKFRPFYLSQLE
3D structure
PDB8i2n The RIPK1 kinase domain in complex with QY7-2B compound
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O4U A E22 D24 I43 V76 M92 E93 M95 G98 H136 L145 D156 L157 F162 E16 D18 I33 V66 M82 E83 M85 G88 H126 L135 D146 L147 F152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8i2n, PDBe:8i2n, PDBj:8i2n
PDBsum8i2n
PubMed38261830
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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