Structure of PDB 8i2b Chain A

Receptor sequence

>8i2bA (length=283) Species: 9606 (Homo sapiens)

APFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTA
SGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLR
FLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMG
LKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGT
SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRL
MKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE

3D structure

• PDB: 8i2b The SIRT6 in complex with inhibitor 7702
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.286: protein acetyllysine N-acetyltransferase.
  2.4.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	O5L	A	I61 P62 F64 F82 N114 V115 D116	I53 P54 F56 F74 N106 V107 D108
BS02	AR6	A	G52 G54 T57 D63 F64 R65 W71 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258	G44 G46 T49 D55 F56 R57 W63 Q105 H125 G199 T200 S201 I204 N225 L226 Q227 Y242 V243
BS03	ZN	A	C141 C144 C166 C177	C133 C136 C158 C162

Gene Ontology

Molecular Function

• GO:0070403 NAD+ binding

External links

• PDB: RCSB:8i2b, PDBe:8i2b, PDBj:8i2b
• PDBsum: 8i2b
• UniProt: Q8N6T7|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)