Structure of PDB 8i1n Chain A

Receptor sequence
>8i1nA (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
HVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPC
YSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFIS
PFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIK
GFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPY
3D structure
PDB8i1n Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G52 A53 G54 K55 T56 T57 I58 R158 V160 T194 T198 V199 G29 A30 G31 K32 T33 T34 I35 R135 V137 T171 T175 V176
Gene Ontology
Molecular Function
GO:0004020 adenylylsulfate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000103 sulfate assimilation

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Molecular Function
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Biological Process
External links
PDB RCSB:8i1n, PDBe:8i1n, PDBj:8i1n
PDBsum8i1n
PubMed37207644
UniProtO95340|PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (Gene Name=PAPSS2)

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