Structure of PDB 8i1m Chain A

Receptor sequence
>8i1mA (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
VSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCY
TLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISP
YTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKG
FTGIDSDYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVP
3D structure
PDB8i1m Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.
ChainA
Resolution1.699 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G64 T67 R168 T204 C207 D208 G30 T33 R134 T170 C173 D174
BS02 ADX A R92 F101 R106 N109 F131 I132 S133 G184 F185 T186 R58 F67 R72 N75 F97 I98 S99 G150 F151 T152
Gene Ontology
Molecular Function
GO:0004020 adenylylsulfate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000103 sulfate assimilation

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Molecular Function
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Biological Process
External links
PDB RCSB:8i1m, PDBe:8i1m, PDBj:8i1m
PDBsum8i1m
PubMed37207644
UniProtO43252|PAPS1_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (Gene Name=PAPSS1)

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