Structure of PDB 8i0h Chain A

Receptor sequence

>8i0hA (length=556) Species: 7227 (Drosophila melanogaster)

MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTF
SPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEK
ERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTI
GDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSV
RELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIY
HVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVC
IAVVGKYTKFTDSYASVVKALQHAALAVNRKLELVFIESCLLEEETLHSE
PSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWARENQKPLLGICL
GLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRL
GKRITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFV
GTDVDKTRMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDR
LNQYIQ

3D structure

• PDB: 8i0h Structural basis of bifunctional CTP/dCTP synthase
• Chain: A
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I11 S12 T149 D245 K309 F310	I11 S12 T149 D245 K309 F310
BS02	DTP	A	G13 V14 G15 K16 G17 V18 K38 H55 D70 V252	G13 V14 G15 K16 G17 V18 K38 H55 D70 V252
BS03	DUT	A	S12 D40 P41 Y42 G147 G148 E154	S12 D40 P41 Y42 G147 G148 E154
BS04	DGT	A	G48 F50 S51 K306 F373 G374 R481	G48 F50 S51 K306 F373 G374 R481

External links

• PDB: RCSB:8i0h, PDBe:8i0h, PDBj:8i0h
• PDBsum: 8i0h
• UniProt: Q9VUL1|PYRG_DROME CTP synthase (Gene Name=Ctps)