Structure of PDB 8hx7 Chain A

Receptor sequence

>8hx7A (length=659) Species: 54571 (Streptomyces venezuelae)

GRHMRTLLIDNYDSFTHNLFQYIGEATGQPPVVVPNDADWSRLPVEDFDA
IVVSPGFGISRRAITDSGLPVLGVCLGHQGIAQLFGGTVGLAPEPMHGRV
SEVRHTGEDVFRGLPSPFTAVRYHSLAATDLPDELEPLAWSDDGVVMGLR
HREKPLWGVQFHPESIGSDFGREIMANFRDLALAHHRARSPYELHVRRVD
VLPDAEEVRRGCLPGEGTTFWLDSSSVLEGASRFSFLGDDRGPLAEYLTY
RVADGVVSVRGSDGTTTRTRRPFFNYLEEQLERRRVPVAPELPFEFNLGY
VGYLGYELKAETTGDPAHRSPHPDAAFLFADRAIALDHQEGCCYLLALDR
RGHDDGARAWLRETAETLTGLAVRMVFGIPEAAAGFGPLARARHDKDAYL
KRIDECLKEIRNGESYEICLTNMVTAPTEATALPLYSALRAISPVPYGAL
LEFPELSVLSASPERFLTIGADGGVESKPIKGTRPRGGTAEEDERLRADL
AGREKDRAENLMIVDLVRNDLNSVCAIGSVHVPRLFEVETYAPVHQLVST
IRGRLRPGTSTAACVRAAFPGGSMTGAPKKRTMEIIDRLEEGPRGVYSGA
LGWFALSGAADLSIVIRTIVLADGQAEFGVGGAIVSLSDQEEEFTETVVK
ARAMVTALD

3D structure

• PDB: 8hx7 Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
• Chain: A
• Resolution: 1.95 Å

Enzymatic activity

• Enzyme Commision number: 2.6.1.85: aminodeoxychorismate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	A	L233 D234 S235 S243 F245 P465 Y466 G467 G621	L222 D223 S224 S232 F234 P446 Y447 G448 G602
BS02	MG	A	S174 D175	S168 D169
BS03	MG	A	E528 A652 E662	E509 A633 E643

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0046820 4-amino-4-deoxychorismate synthase activity

Biological Process

• GO:0006541 glutamine metabolic process
• GO:0008153 para-aminobenzoic acid biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0017000 antibiotic biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8hx7, PDBe:8hx7, PDBj:8hx7
• PDBsum: 8hx7
• PubMed: 37712435
• UniProt: F2RB79|ADCS_STRVP Aminodeoxychorismate synthase (Gene Name=cmlB)