Structure of PDB 8hx6 Chain A

Receptor sequence

>8hx6A (length=660) Species: 54571 (Streptomyces venezuelae)

RHMRTLLIDNYDSFTHNLFQYIGEATGQPPVVVPNDADWSRLPVEDFDAI
VVSPGPGSPGISRRAITDSGLPVLGVCLGHQGIAQLFEPMHGRVSEVRHT
GEDVFRGLPSPFTAVRYHSLAATDLPDELEPLAWSDDGVVMGLRHREKPL
WGVQFHPESIGSDFGREIMANFRDLALAHHRARRHGADSPYELHVRRVDV
LPDAEEVRRGCLPGEGTTFWLDSSSVLEGASRFSFLGDDRGPLAEYLTYR
VADGVVSVRGSDGTTTRTRRPFFNYLEEQLERRRVPVAPELPFEFNLGYV
GYLGYELKAETTGDPAHRSPHPDAAFLFADRAIALDHQEGCCYLLALDRR
GHDDGARAWLRETAETLTGLAVRAPAEFGIPEAAAGFGPLARARHDKDAY
LKRIDECLKEIRNGESYEICLTNMVTAPTEATALPLYSALRAISPVPYGA
LLEFPELSVLSASPERFLTIGADGGVESKPIKGTRPRGGTAEEDERLRAD
LAGREKDRAENLMIVDLVRNDLNSVCAIGSVHVPRLFEVETYAPVHQLVS
TIRGRLRPGTSTAACVRAAFPGGSMTGAPKKRTMEIIDRLEEGPRGVYSG
ALGWFALSGAADLSIVIRTIVLADGQAEFGVGGAIVSLSDQEEEFTETVV
KARAMVTALD

3D structure

• PDB: 8hx6 Structural basis for the allosteric pathway of 4-amino-4-deoxychorismate synthase.
• Chain: A
• Resolution: 2.14 Å

Enzymatic activity

• Enzyme Commision number: 2.6.1.85: aminodeoxychorismate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	A	L233 D234 S235 S243 F245 P465 Y466 G467 G621	L221 D222 S223 S231 F233 P447 Y448 G449 G603
BS02	MG	A	S174 D175	S162 D163

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0046820 4-amino-4-deoxychorismate synthase activity

Biological Process

• GO:0006541 glutamine metabolic process
• GO:0008153 para-aminobenzoic acid biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0017000 antibiotic biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8hx6, PDBe:8hx6, PDBj:8hx6
• PDBsum: 8hx6
• PubMed: 37712435
• UniProt: F2RB79|ADCS_STRVP Aminodeoxychorismate synthase (Gene Name=cmlB)