Structure of PDB 8hwf Chain A

Receptor sequence
>8hwfA (length=378) Species: 10244 (Monkeypox virus) [Search protein sequence]
GNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLITKLILSIR
HQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPFKNGVLDL
VDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNIINDIQPLT
DENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRLLKSAIGD
LFVETGQTILTDVLDKGPNPFIANMHLKRSVFCSELPDFACSGSKKIRSD
NIKKLTEPCVIGRPCFSNKINNRNHATIIIDTNYKPVFDRIDNALMRRIA
VVRFRTHFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLL
VKWYKKYHIPIMKLYPTPEEIPDFAFYL
3D structure
PDB8hwf Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
ChainA
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R585 C587 F588 R263 C265 F266
BS02 ADP A I464 T505 A506 T507 G508 K509 S510 F630 D652 L655 I142 T183 A184 T185 G186 K187 S188 F308 D330 L333
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8hwf, PDBe:8hwf, PDBj:8hwf
PDBsum8hwf
PubMed38177671
UniProtA0A7H0DN89|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

[Back to BioLiP]